Duration
15h Th, 10h SEM
Number of credits
| Master in chemistry (120 ECTS) | 3 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
This course is organized as follows: Chapter 1: General properties of enzymes. Chapter 2: Steady-state kinetics. Chapter 3: Enzyme inhibition. Chapter 4: Effect of pH, temperature, viscosity and other experimental factors. Chapter 5: Reactions of two substrates. Chapter 6: Transient-state kinetics. Chapter 7: Cooperativity and allosteric interactions. Chapter 8: Enzyme inactivators. Chapter 9: Enzyme cofactors. Chapter 10: Mechanism of chymotrypsin. Chapter 11: Basic catalytic principles. Chapter 12: Regulation of catalytic activity.
Learning outcomes of the learning unit
The aim of the course is to make students familiar with enzyme mechanisms and fundamentals of enzyme kinetics.
Prerequisite knowledge and skills
Course on "Biochemistry" (BAC Chemistry), which includes an introduction to enzyme catalysis (chapters 1-3).
Planned learning activities and teaching methods
Students read and study the notes on their own. For each chapter, a meeting is possibly organized with the professor to discuss certain difficult points.
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face course
Additional information:
Face-to-face only
Recommended or required readings
Lecture notes will be available.
Reference book:
A. Cornish-Bowden, Fundamentals of enzyme kinetics, fourth edition, Wiley-Blackwell, 2012.
A.R. Fersht, Structure and mechanism in protein science, W.H. Freeman and Co, 1999.
Exam(s) in session
Any session
- In-person
oral exam
Additional information:
The evaluation will be made on the basis of an oral presentation relating to the analysis of a few articles.
Work placement(s)
Non applicable
Organisational remarks and main changes to the course
It is up to the students to contact the professor at the beginning of the teaching period.
Contacts
André Matagne, PhD, Full Professor, Enzymology and Protein Folding, Centre for Protein Engineering, Life Science Department, Institut de Chimie B6c (room 3/61), Quartier Agora, Allée du 6 Août, 13, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Email: amatagne@ulg.ac.be