Duration
40h Th, 10h SEM
Number of credits
| Bachelor in pharmacy | 5 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Systematic part 2 : drugs of the central nervous system, drugs of the peripheral nervous system, local anaesthetics, antihistaminics, drugs of the cardiovascular system, of the renal system and of the blood, drugs of the respiratory system, drugs of the gastrointestinal tract, of the metabolic and nutritional disorders, hormones, dermatological drugs, contrast products, miscelleanous.
Learning outcomes of the learning unit
Medicinal chemistry is a science devoted to the design, the synthesis and the understanding of the mode of action of drugs, and more specifically, those obtained by organic synthesis. This science tries to establish a link between the chemical structure of a drug and its biological activity.
The general aims of this course are the following : to familiarize the student with the active components of drugs, their chemical structures, their origin, their design, their evolution, the field of their therapeutic applications, their international nonproprietary names and several examples of trade marks. Some examples of synthesis are provided, the general physicochemical properties are reviewed. The systematic part is introduced by the presentation of the traditional and innovative steps in drug design, by the review of classical synthetic processes and by a summary of the I.U.P.A.C. nomenclature.
At the end of this training, the student must be able to:
- understand how drugs are designed (drug design), prepared (organic synthesis, genetic engineering) and named (i.e. nomenclature of heterocyclic compounds);
- establish relationships between the chemical structure of the drugs and their biological and therapeutic action (structure-activity relationships), as well as the main physico-chemical properties (solubility, acido-basic character, stability, chirality, ...);
- know/recognize the main drugs on the Belgian market by their name (INN, trademark) and their chemical structure and to locate them in their pharmacological class (main therapeutic uses).
Prerequisite knowledge and skills
Appropriate knowledge of inorganic and organic chemistry, basic knowledge of physiology.
Planned learning activities and teaching methods
Seminars (10 h) : revision of selected theoretical aspects ; solubility, hydrophilicity and lipophilicity associated with drugs; acido-basic character of drugs; importance of the stereochemistry; case studies of drug design; use of the metabolomic approach in medicinal chemistry; identification of new biological targets; notions of ADME.
Mode of delivery (face to face, distance learning, hybrid learning)
The lessons (2 h) are usually given twice weekly during the second quadrimester.
Recommended or required readings
Written notes upgraded each year are distributed to the students.
Exam(s) in session
Any session
- In-person
written exam ( multiple-choice questionnaire, open-ended questions )
Additional information:
Written exam in may-june (first session).
Written exam in august-september (second session).
An oral rattrapage exam may be organized in June for students with a note > or = to 8/20 and < to 10/20.
The first and second session exam will partly include questions of the true/false type, MCQ and short answer questions. Other kinds of questions could also be introduced (i.e. table with structures, INN, commercial names, ...).
Work placement(s)
Organisational remarks and main changes to the course
Contacts
Professeur Bernard PIROTTE Laboratoire de Chimie Pharmaceutique Quartier Hôpital, 15, Avenue Hippocrate, B-4000 Liège C.H.U. - tour 4 - niveau + 5 (Bât. B36) tel : 04 366 43 65 - fax : 04 366 43 62 e-mail: B.Pirotte@uliege.be Secrétariat : Mme Annabelle HAMANDE (tel : 04 366 43 61)