Duration
20h Th, 25h Pr
Number of credits
| Bachelor in chemistry | 4 crédits |
Lecturer
Coordinator
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
The course aims to give students a logical method of identifying unknown molecules based on a set of spectra. The course emphasizes the complementarity of physico-chemical methods, including mass spectrometry, infrared spectroscopy, UV-Visible spectroscopy and nuclear magnetic resonance. The methods are introduced successively, by means of examples whose resolution requires the cumulative contribution of the techniques introduced at this moment of the course. Mass spectrometry and associated methods (MS / MS) are essential methods widely used in the chemical industry and control laboratories. It requires a good knowledge of basic chemistry and reactivity in organic chemistry as well as the interpretation of isotopic distributions. Nuclear magnetic resonance is an important second part of the course. It comes in addition to the notions introduced in Organic Chemistry and Physical Chemistry. The use of 1 H and 13 C NMR as well as the basic notions of two-dimensional NMR (2D NMR) are amply illustrated. Examples also include organometallic compounds with non-zero spin central atoms. The course gives a large part to the resolution of exercises.
Learning outcomes of the learning unit
The objectives of the course are to gather the theoretical and experimental tools necessary to the determination of the structure of organic, organometallic and biological molecules and to describe the method of optimal use of spectroscopic information to determine an univocal structure, at least until connectivities.
Prerequisite knowledge and skills
General Organic Chemistry
General Physical Chemistry
Planned learning activities and teaching methods
Problem solving sessions of increasing complexity, in sync with the techniques gradually seen during, under the supervision of an assistant. These exercises prepare for a working method allowing for proper management of time and information. Access to spectral databases (ULgSpectra) and familiarization with measuring instruments will also be provided
Mode of delivery (face to face, distance learning, hybrid learning)
Reference books More Spectroscopic Problems in Organic Chemistry (Spectroscopy in Chemical Education, Baker et al, Heyden, 1967) Organic Structure from Spectra (Sternell et Kalman, Wiley, 1987) Spectrometric Identification of Organic Compounds (Silverstein, Bassler et Morill, Wiley, Ed7, 2005)
Recommended or required readings
Reference books More Spectroscopic Problems in Organic Chemistry (Spectroscopy in Chemical Education, Baker et al, Heyden, 1967) Organic Structure from Spectra (Sternell et Kalman, Wiley, 1987) Spectrometric Identification of Organic Compounds (Silverstein, Bassler et Morill, Wiley, Ed7, 2005)
Any session :
- In-person
written exam ( open-ended questions )
- Remote
written exam ( open-ended questions )
- If evaluation in "hybrid"
preferred in-person
Additional information:
Written exam. Knowlege and understanding of the theory and basic principle will be evaluated. the ability to apply the theory will be evaluated by the analysis of unknown compounds using multiple spectra.
Work placement(s)
Organisational remarks and main changes to the course
Contacts
Pr. Christian Damblon
Institut de Chimie, Bât. B6, 4000 Liège 1, Sart Tilman
e-mail: c.damblon@ulg.ac.be
Prof. Loïc Quinton
Laboratory of Mass Spectrometry - Biological Chemistry
MolSys Research Unit
Allée du six Aout 11 - Quartier Agora
B4000 -Liège 1 - Belgium
Tel +32 4 366 3679
loic.quinton@uliege.be
Sophie Rappe, doctorante, Assistante
e-mail:sophie.rappe@ulg.ac.be