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| Version 2011-2012 |
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| GENE0120-2 | Normal and pathological human biochemistry and physiology, part : molecular genetics
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| Duration : | 10h Th, 10h Pr, 5h SEM |
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| Number of credits : |
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| Lecturer : | Vincent Bours |
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Language(s) of instruction :
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| French language |
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Course contents :
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| The course presents the molecular characteristics of the human genome and its functioning. It describes the preservation and repair mechanisms of the genome. The course presents genome exploration techniques used in biomedical research and genetic diagnostics.
Chapter 1: DNA structure
Chapter 2: Chromosomes and chromatin
Chapter 3: DNA replication
Chapter 4: Mutations and DNA repairs
Chapter 5: Transcription and its regulation
Chapter 6: Translation
Chapter 7: Genome exploration: medical applications |
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Learning outcomes of the course :
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| - Understand DNA packing and its functional consequences.
- Describe the main stages of DNA replication, transcription, and translation.
- Understand and describe the main DNA repair mechanisms and the consequences of their malfunction.
- Understand and explain induced and spontaneous mutations. Define a mutagen and provide examples
- Describe the maturation mechanisms of messenger RNA.
- Explain transcription control mechanisms.
- Explain the main protein post-translation modifications (glycosylation, phosphorylation, ubiquitination, translocation, spilt) and their functional roles.
- Understand the human genome exploration methods. Understand the techniques and their specificities. |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Review and understand genomic structure and the main genetic anomalies (1st year course). |
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Planned learning activities and teaching methods :
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| The students can take part in lab demos and observe basic manipulations in genetic diagnostic (karyotype definition, DNA extraction, enzymatic restriction, sequencing, PCR). |
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Mode of delivery (face-to-face ; distance-learning) :
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| 10 hours, 1st quadrimester
+ 10 hours of practical exercises |
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Recommended or required readings :
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| - Analyse Génétique Moderne by Griffiths, Gelbart, Miller and Lewontin, De Boeck Université
- Genes VII by Benjamin Lewin, Oxford University Press (see above). (http://www.oup.co.uk/best.textbooks/biochemistry/genesvii/illustrations/). |
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Assessment methods and criteria :
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| Written exam in January with multiple-choice and open short-answer questions.
Second exam session: written exam (open short-answer questions). |
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Training(s) :
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Organizational remarks :
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Contacts :
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| Main lecturer
Bours Vincent, Professeur
CHU B35
Telephone: 04-3668145
E-mail: vbours@ulg.ac.be
Secretary:
Fertons Marianne
Telephone: 04-3668145
E-mail: genetique.humaine@ulg.ac.be |
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