Duration
16h Th
Number of credits
| Master in pharmacy (120 ECTS) | 2 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Contents
The cours will be separated in 4 parts including:
-I-a Antimicrobial agents
- Revision
- Emergence of multi-resistant bacteria
- Ecology of resistance
- Role of the pharmacist and educational tools towards a better use of antibiotics
- Ib- Antifungals
- Refresh on fungal infections
- Refresh on the different antifungals available
- Mechanisms of restistance to antifungals
- Laboratory methods for the detection of antifungal resistance
- Clinical Case
-II- Quality assurance for drug production
- Introduction
- Contaminations: risks, causes and outcomes
- Control of the level of contamination (Microorganisms, transmission; GMP and QA; systems of reference; testing methods; preservative systems; microbiological methods; Preservative efficacy testing; disinfectant efficacy testing.)
-III - Sterilisation - disinfection
- Introduction
- Microbial targets
- Definitions and goals
- Sterilization methods:
Physical procedures (dry and moist heat, air and liquid filtration, irradiation)
Gazeous sterilization (ethylene oxyde, formaldehyde, plasma H2O2)
Chemical agents (peracetic acid)
Sterilization control and sterility assurance
- Antiseptics and disinfectants
-IV- Vaccines
- Introduction
- Vaccines strategies
- types of vaccines
- Conjugation
- Adjuvants
- Recommended vaccines in Belgium
Learning outcomes of the learning unit
At the end of this course, students will be able to
- list and give characteristics of the main antibiotics used at hospital or in ambulatory care.
- provide useful recommendations and explanations for the best compliance to an antimicrobial treatment.
- argue why all types of infections don't need to be treated with antibiotics.
- explain the role of antibiotic pressure on emergence of resistance.
- Understand and describe the different mechanism of resistance to antifungals
- To direct the treatment towards a given antifungal according to the constitutive or acquired resistances of different species of fungi.
- To understand the epidemiology of antifungal resistance.
- Describe the laboratory methods available on the market for the detection of resistance to antifungals.
- To understand via a clinical case, the possible therapeutic pathway in case of fungal infection with resistance.
- describe the impact of contaminations on pharmaceutical products.
- decribe characteristics and sources of contaminating microbial agents.
- summurize basis of GMP related to microbiological quality.
- explain the principle and limits of sterility tests.
- understand the requirements for production under appropriate controlled microbiological conditions.
- summarize the main sterilization methods and their characteristics, to be used in industry, at hospital or in the dispensory.
- discuss the indications and limits of the main antiseptics and disinfectants.
- describe the different types of vaccines, their indications, side effects, target population.
- explain the expected goals of glycoconjugation and used of adjuvants in vaccine technology.
- list the compulsory vaccines in Belgium.
- explain the goal of booster.
Prerequisite knowledge and skills
Prerequisite or corequisite units are presented within each program.
Planned learning activities and teaching methods
The course will be taught as lectures, supported by PowerPoint-type slides.
From time to time, short Quiz are proposed to attract students' attention and to check their knowledge before and/or after a teached chapter.
Students are invited to ask their questions after the lecture or by email.
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face course
Additional information:
Face-to-face or visioconference or podcasts.
Recommended or required readings
Slide sets of all lectures are available on the university website with a "myULg" access.
A non exhaustive list of text-books can also be useful but they are not necessary.
- Hugo&Russell's Pharmaceuticals microbiology, S.Denyer, N. Hodges, S. Gorman, B. Gilmore, 8th Ed. 2011, Wiley-Blackwell
- Microbial Quality Assurance in Pharmaceuticals, Cosmetics, and Toiletries, R. Baird, Sally F. Bloomfield, Taylor andFrancis, 1996
- Vaccine design: Innovative Approaches and Novel Strategies, R Rappuoli et F Bagnoli, Caister Academic Press, 2011
- Vaccinologie, J. Gaudelus, Doin editeurs, 2008
- Medical microbiology, Mims C. et al, 5th Ed.,2012, Elsevier
- Bactériologie médicale, F.Denis, MC. Ploy, C. Martin, E. Bingen, R. Quentin et al. 2ème Ed., 2011, Masson Paris
Any session :
- In-person
written exam ( multiple-choice questionnaire )
- Remote
written exam ( multiple-choice questionnaire )
- If evaluation in "hybrid"
preferred in-person
Additional information:
Written exam : questions with multiple choice
Work placement(s)
Student assistant: opportunities are given to students interested in teaching Microbiology. The work mainly consists of supervising laboratory workshop.
Internship opportunity during the last year of master (final thesis).
Organisational remarks and main changes to the course
Contacts
Clinical microbiology Department
University Hospital of Liège,
B-23 Sart Tilman,
4000 LIEGE
Belgium
Secretary
For any contact or to fix an appointment, please contact the secretary Mrs Wauquier
- Phone : 00.32.4.323.22.90
- Telecopy: 00.32.4.366.24.40
- email : stéphanie.wauquier@chuliege.be
Marie-Pierre Hayette, (mphayette@uliege.be)
Sébastien Bontems (sbontems@chuliege.be)
Aurore NAPP (Aurore.Napp@chuliege.be)
Gaëtan Vanharen (gvanharen@chuliege.be)
Rosalie Sacheli (R.Sacheli@chuliege.be)