Duration
Visites industrielles : 6h Vis. Ind. Pl.
Introduction à la biologie clinique : 6h SEM
Médicaments d'origine biosynthétique : 6h SEM
Stratégies de découverte des médicaments : 3h SEM
Chimie structurale des médicaments : 3h SEM
Management pharmaceutique : 3h SEM
Assurance de qualité : 3h SEM
Technologie pharmaceutique industrielle : 3h SEM
Analyses biopharmaceutiques : 6h SEM
Affaires règlementaires : 3h SEM
Etudes cliniques : 3h SEM
Méthodologie de rédaction : 3h SEM
Number of credits
| Master in pharmacy (120 ECTS) | 10 crédits |
Lecturer
Visites industrielles : Brigitte Evrard, Marianne Fillet, Philippe Hubert
Introduction à la biologie clinique : Corinne Charlier, Marie-Pierre Hayette, Caroline Le Goff
Médicaments d'origine biosynthétique : Pierre Francotte
Stratégies de découverte des médicaments : Bernard Pirotte
Chimie structurale des médicaments : Pascal De Tullio, Michel Frederich
Management pharmaceutique : Walid El azab
Assurance de qualité : Philippe Hubert, Roland Marini Djang'Eing'A
Technologie pharmaceutique industrielle : Brigitte Evrard
Analyses biopharmaceutiques : Marianne Fillet
Affaires règlementaires : Philippe Hubert
Etudes cliniques : Régis Radermecker
Méthodologie de rédaction : Geneviève Philippe
Coordinator
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Not available
Introduction à la biologie clinique
This course tends to present the clinical biology laboratory in his different aspects.
Here are presented particularly the laboratories of toxicology, microbiology and genetics.
A core of teacher will present the course with the objective to describe the most recent advances in the field.
For example for the microbiology part, the table of content is as follows:
Table of contents (Microbiology, MP Hayette)
1-présentation of clinical biology laboratories
2-application of mass spectrometry in microbiology
3-application of molécular biology techniques: real-time PCR, quantitative and qualitative, sequençing and NGS.
Table des matières (Genetics, F Boemer)
1- application of mass spectrometry in genetics
2- application of mass spectrometry in proteomics
3- application of mass spectrometry in imaging
4-application of high-throughput sequencing technologies for prenatal diagnosis of aneuploidies (ie. trisomy 21, 13,...)
Médicaments d'origine biosynthétique
The lectures will browse the different claasses of macromolecules, antibodies and vaccines available (or soon) on the market. For each class, structural features will be discussed, as well as development strategies, production and PD/PK properties.
Stratégies de découverte des médicaments
Strategies and tools used in drug design; notions of "drugability" and "drug likeness", importance of physicochemical properties in the selection of drug candidates, ADME-Tox concepts, use of the computational tool, contribution of molecular biology.
Chimie structurale des médicaments
General approach of the different methods (principally spectroscopic ones) used to determine the chemical structure of organic compounds.
Management pharmaceutique
n/a
Assurance de qualité
...
Technologie pharmaceutique industrielle
Industrial production of pharmaceutical dosage forms
Analyses biopharmaceutiques
Biopharmaceuticals
*Definition
*Production (Synthesis, Purification and Formulation)
*Distinct attributes (Physicochemical and Physiological characteristics)
*Physical and chemical stability
*Quality control
*Biosimilars
Méthodologie de rédaction
This course aims to provide concrete methodological support to students in the context of the realization of their personal research work associated with their internship with option of master's degree, specialized ends. The general instructions concerning the work requested will be detailed during the course. In parallel, practical advice will be provided on each stage of the work: from the definition of the research topic to the oral defense, focusing primarily on the writing of the work (document structure, writing rules, bibliographic referencing, etc.) .
Learning outcomes of the learning unit
Introduction à la biologie clinique
At the end of the course,n the students will be aware of the orgnaisation mode of the laboratories of clinical biology in Belgium but also the future developments which will be introduced in the next future.
Médicaments d'origine biosynthétique
The goal of these lectures is to give a general overview of the biopharmaceutics world with their advantages, the current trends and a comparison with the "small molecules" world.
Stratégies de découverte des médicaments
The main objective of the course is to give students information on strategic approaches currently used in the pharmaceutical industry in the drug discovery process.
Chimie structurale des médicaments
Practical approach of the different methods (principally spectroscopic ones) used to determine the chemical structure of organic compounds
Management pharmaceutique
n/a
Assurance de qualité
...
Technologie pharmaceutique industrielle
General learning outcomes
i. advanced learning of the aspects of formulation and industrial aspects of the production of drugs ;
ii . Knowledge of the excipients used in the manufacture of solids, liquids and pasty
specific learning outcomes
i . Getting to the industrial production environment
ii . Knowledge of industrial production stages of solid oral dosage forms.
Analyses biopharmaceutiques
The students should apprehend the differences between medicines resulting from the chemcal synthesis and biotechnology in terms of production, stability and quality control.
Méthodologie de rédaction
This course will guide the student in writing his own research work, both in terms of the general research method (the disciplinary specificities are, of course, under the responsibility of the promoters and addressed during the course) that in the form what should the manuscript take. He will be aware of the responsibilities incumbent on him when writing a scientific writing (absence of plagiarism, correct referencing, quality of scientific results, etc.).
Prerequisite knowledge and skills
Introduction à la biologie clinique
Knowledge acquired during the studies.
Médicaments d'origine biosynthétique
Organic & medicinal chemistry, pharmacology, physio(patho)logy and principles of immunology.
Stratégies de découverte des médicaments
Medicinal chemistry, pharmacology.
Chimie structurale des médicaments
Organic chemistry, Physics, Analytical Chemistry.
Technologie pharmaceutique industrielle
Pharmaceutical Technology and Biopharmacy
Analyses biopharmaceutiques
- analytical chemistry
- drug analysis
Méthodologie de rédaction
Practice of French required
Planned learning activities and teaching methods
Introduction à la biologie clinique
Diaporama and video's. Conversations with the students.
Médicaments d'origine biosynthétique
Lectures in face to face mode; syllabus, slides and textbook will be available on eCampus.
Stratégies de découverte des médicaments
Theoretical course via a ppt presentation, the content of which is made available to students.
Chimie structurale des médicaments
No practicals
Management pharmaceutique
n/a
Technologie pharmaceutique industrielle
...
Méthodologie de rédaction
Sessions in classroom. Attendance at the course is not obligatory.
Mode of delivery (face to face, distance learning, hybrid learning)
Blended learning
Additional information:
not available
Introduction à la biologie clinique
Face to face teaching method or online or podcasts
Médicaments d'origine biosynthétique
Face-to-face course
Chimie structurale des médicaments
---
Management pharmaceutique
Blended learning
Assurance de qualité
...
Technologie pharmaceutique industrielle
A 3 hours lesson is organised
Analyses biopharmaceutiques
face-to-face and flipped classroom
Méthodologie de rédaction
Face-to-face course - Presence is not mandatory. However, information disseminated in the course will not be repeated individually.
Recommended or required readings
Introduction à la biologie clinique
Slides available online.
Médicaments d'origine biosynthétique
Textbooks will be proposed and shared.
Chimie structurale des médicaments
The slides projected during the course will be distributed to students (eCampus).
Management pharmaceutique
n/a
Analyses biopharmaceutiques
slides on e-campus
monographies on e-campus
Méthodologie de rédaction
Consultation of previous work for illustrative purposes
Assessment methods and criteria
Exam(s) in session
Any session
- In-person
written exam ( multiple-choice questionnaire )
- Remote
written exam ( multiple-choice questionnaire )
Additional information:
Written exam ("true-false")
Introduction à la biologie clinique
Any session :
- In-person
written exam ( multiple-choice questionnaire )
- Remote
written exam ( multiple-choice questionnaire )
- If evaluation in "hybrid"
preferred in-person
Additional information:
...
Médicaments d'origine biosynthétique
Exam(s) in session
Any session
- In-person
written exam ( multiple-choice questionnaire, open-ended questions )
Chimie structurale des médicaments
Exam(s) in session
Any session
- In-person
written exam ( multiple-choice questionnaire )
Additional information:
Written exam
Management pharmaceutique
Exam(s) in session
January exam session
- In-person
written exam ( multiple-choice questionnaire )
- Remote
written exam ( multiple-choice questionnaire )
August-September exam session
- In-person
written exam ( multiple-choice questionnaire )
- Remote
written exam ( multiple-choice questionnaire )
Additional information:
n/a
Assurance de qualité
...
Technologie pharmaceutique industrielle
QCM
Analyses biopharmaceutiques
20 questions on this partim (Y/N)
Méthodologie de rédaction
None
Work placement(s)
Management pharmaceutique
n/a
Organisational remarks and main changes to the course
Chimie structurale des médicaments
coming soon
Assurance de qualité
...
Méthodologie de rédaction
Interventions are made by Mrs Anne-France Lanotte and Mrs Marjorie Bardiau
Contacts
Coordination : Prof. PIROTTE Bernard (b.pirotte@uliege.be )
Introduction à la biologie clinique
Pedagogic coordinator: Geneviève Colinet
Core of teachers: François Boemer, Marie-Pierre Hayette, Corinne Charlier
Médicaments d'origine biosynthétique
Pierre.Francotte@uliege.be - +32 4366 4369
Stratégies de découverte des médicaments
Professeur Bernard PIROTTE Laboratoire de Chimie Pharmaceutique Quartier Hôpital, 15, Avenue Hippocrate, B-4000 Liège C.H.U. - tour 4 - niveau + 5 (Bât. B36) tel : 04 366 43 65 - fax : 04 366 43 62 e-mail: B.Pirotte@uliege.be Secrétariat : Mme Annabelle HAMANDE (tel : 04 366 43 61)
Chimie structurale des médicaments
Prof Dr Michel Frédérich,
Laboratoire de Pharmacognosie
Avenue de l'hôpital 1, B-4000 Liège
CHU Tour 4, niveau +3 (B36)
Tél. 04/366 43 38
Fax. 04/366 43 32
E-mail: M.Frederich@ulg .ac.be
Pascal De Tullio, FNRS Research Director
Laboratoire de Chimie Pharmaceutique
Avenue de l'hôpital 1, B-4000 Liège
CHU Tour 4, niveau +5 (B36)
Tél. 04/366 43 69
E-mail : P. deTullio@ulg.ac.be
Assurance de qualité
...
Technologie pharmaceutique industrielle
Brigitte Evrard, Professeur ordinaire
b.evrard@uliege.be
Analyses biopharmaceutiques
Marianne Fillet
Laboratoire d'Analyse de Médicaments
marianne.fillet@ulg.ac.be
04/3664345
Méthodologie de rédaction
Geneviève Philippe
g.philippe@uliege.be
Association of one or more MOOCs
Management pharmaceutique
There is no MOOC associated with this course.
Additional information:
n/a
Items online
Introduction à la biologie clinique
PODCAST "Du bon usage du laboratoire"
PODCAST "Du bon usage du laboratoire"