Animal genomic

Duration

28h Th, 10h Mon. WS

Number of credits

Lecturer

Michel Georges

Language(s) of instruction

French language

Organisation and examination

Teaching in the second semester

Schedule

Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

BSc course: Essential genomics for veterinarians and the animal sciences.  

 
"Essential genomics for veterinarians and the animal sciences" provides a general introduction to the field of genomics applied to domestic animals.

 
The course comprises a total of eight sections corresponding respectively to

Prerequisites I: Fundamentals in molecular biology of the gene

Prerequisites II: Fundamentals in genetics

Chapter I: Reference genomes

Chapter II: Individual genomes

Chapter III: Individual phenomes

Chapter IV: Genetic dissection of the functional circuitry

Chapter V: Fundamentals of animal selection

Chapter VI: Applied animal genomics


The first 4 ½ sections will be given to the veterinary students in their second bachelors year.  The remaining 3 ½ sections will be given to the veterinary students in their first masters year.

Learning outcomes of the learning unit

At the end of this course, the student will be familiarized with:

• The organisation and main features of the animal genome, sequencing technologies and methods used for the annotation of reference genomes.
• Basic concepts in population and evolutionary genomics including the different types of genetic variants, the origins of genetic polymorphism, the notion of linkage disequilibrium and haplotype blocks, the main genotyping methods, the methods used for the reconstruction of our evolutionary history and of animal domestication.
• Basic concepts in factorial and quantitative genomics including the distinction between mono-, oligo- and polygenic traits, the molecular basis of dominance and recessivity, the different types of epistatic interactions. The student will understand the relative contribution of germline and somatic mutations/variants in the development of cancers.

Prerequisite knowledge and skills

1. Basic knowledge in molecular biology of the gene (structure of DNA/RNA/proteins, replication, transcription, translation, mitosis, meiosis) and mendelian genetics (Mendel's laws, dominance, recessivity, linkage)

2. Basic knowledge in probability and statistics (mean, variance, covariance, correlation).

Planned learning activities and teaching methods

The bachelors course comprises 28 hours of theoretical "ex cathedra" courses (Prerequistes I&II: 6 hours; Chapter I: 8 hours; Chapter II: 8 hours; Chapter IIIA: 4 hours; 2 hours of buffer time), as well as 10 hours of practicals.

During the practicals, the students will be given extra material to better understand the theory, multiple choice questions (MCQ) that probe their understanding of the theory, as well as problems pertaining to sections 1 to 4 ½ of the course. They will work under supervision of one or more teaching assistants. The organization of the practical work will take place in a hybrid way: online and face-to-face.

Attendance at practical work is mandatory.

An unjustified absence from the practical sessions will not allow the student to perform the exam in the first session.

Mode of delivery (face to face, distance learning, hybrid learning)

Face-to-face course


Additional information:

Face-to-face courses

Recommended or required readings

The subject matter of the course corresponds to the content of the textbook that can be downloaded from GIGAUAG - Teaching as well as from ULiège's eCampus website.  As additional support, the students will have access (through the same web-pages) to copies of the slides that are used by the teacher during the ex-cathedra courses.  These slides correspond to a large extent to the figures and tables of the textbook.  Slides will be made as the course progresses.  Updates of the lecture notes will be made available as the course progresses.

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire )

Written work / report


Additional information:

Written exam including multiple choice questions (+1; 0 ; -1 /NSP-1).


Exercises will be due during the week of the TD and will count for 10% of the final grade.

 
Students absent from the TD will have a homework and it wiil count for 10% of the final grade.

Work placement(s)

Not applicable

Organisational remarks and main changes to the course

Contacts

Michel.Georges@uliege.be

chupperts@uliege.be

 

Association of one or more MOOCs

Items online