2023-2024 / BIOC1004-1

Biochemistry and normal and pathological human physiology

Cardiovascular system

Respiratory system

Endocrine system and metabolism

Nervous system

Digestive system

Nephro-urinary system

Duration

Cardiovascular system : 10h Th
Respiratory system : 10h Th
Endocrine system and metabolism : 15h Th
Nervous system : 20h Th
Digestive system : 15h Th
Nephro-urinary system : 10h Th

Number of credits

 Bachelor in pharmacy12 crédits 

Lecturer

Cardiovascular system : Philippe Kolh
Respiratory system : Didier Cataldo
Endocrine system and metabolism : Philippe Kolh
Nervous system : Gaëtan Garraux
Digestive system : Didier Cataldo
Nephro-urinary system : Didier Cataldo

Coordinator

Didier Cataldo

Language(s) of instruction

French language

Organisation and examination

Teaching in the second semester

Schedule

Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

The course aims at allowing students to be able to understand human biochemistry and physiology
The different systems will be part of the course:
I. Cardio-vascular system. 
1. Elements of cardio-vascular physiology 2. Cardiac pump 3. Vascular System 4. Cardio-vascular homeostasis : cardiac output and arterial pressure 5. Principles of cardio-vascular physiopathology 6. Arterial hypertension 7. Coronary insufficiency 8. Cardiac failure

II. Respiratory system
1. Introduction to respiratory system 
2. Ventilation
3. Diffusion 
4. Circulation
5. Blood gazes
6. Control of pH
7. Gaz exchanges
8. Respiratory mechanics
9. Control of ventilation
10. Unusual conditions (altitude...). 
  III. Digestive system 
1. Introduction
2. Regulation processes
3. Energy and metabolism
4. Regulation of intakes
5. Mouth
6. Oesophagus
7. Stomach
8. Hormons of digestive tract
9. Pancreas
10. Intestine absorption 
11. Liver 
12. Colon 
  IV. Nephro-urinary system 
1. Introduction
2. Glomerular filtration
3. Tubular function
4. Water and ions regulation
5. Kidney pathophysiology 
6. Urinary tract physiology

V. Endocrine system and metabolism

The course concerns human biochemistry and physiology, partim endocrine system and metabolism. In particular, it encompasses the following chapters:
1. Introduction
2. Mechanisms of action of hormones
3. The hormones of the energetic metabolism
   Energetic metabolism
   Insulin and diabetes
   Glucagon
   Epinephrine
   Glucocorticoids
   Thyroid hormones
4. Gastro-intestinal hormones
5. Water, electrolytes, and mineral elements
6. Growth
7. Reproduction
8. Cytokines
9. Mediators
 
VI Nervous system
Système sensoriels somatiques : somesthésie, vision, audition, gustation, olfaction
Système moteur somatique : unité motrice, contrôle segmentaire des unités motrices, contrôle supra-segmentaire, apprentissage
Cognition, émotion, comportement
Eveil et conscience
Homéostasie


 

Cardiovascular system

The subject of this module relates to  Normal and Pathological Human Biochemistry and Physiology, partim cardiovascular system, broken down in the following chapters:  
The heart pump (Chapters I to V):  
- Functional architecture (Chapter I)      
   - Heart chambers      
    - Valvular apparatus  
- The automaticity of the pump (Chapter II)
    - The action potential  
    - Neuro-vegetative modulation
- The cardiac cycle (Chapter III)
   - The driving unit
   - The pressure-volume loop  
- Ventricular performance (Chapter IV)
   - The concept of preload
   - The concept of afterload
   - The concept of contractility  
- Myocardial energetics (Chapter V)
The vascular system (Chapter VI):  
- The laws of blood flow (Chapter VI)
   - Bernoulli's law
   - Darcy's law
   - Hagen-Poiseuille's law
- Functional architecture (Chapter VI)
   - Vascular resistance
   - Arterial elasticity  
- The blood pressure wave (Chapter VI)  
- Vasomotricity (Chapter VI)    
   - Mechanical self-regulation
   - Metabolic self-regulation
   - The endothelial function  
Cardiovascular control (Chapter VII)
- The relationships of cardiac output
- Control of blood pressure
   - The barosensitive reflex
   - Hormonal regulation  
Elements of cardiovascular physiopathology (Chapters VIII and X)
- Pressure overload (Chapter VIII)
- Volume overload (Chapter VIII)
- Breach of contractility (Chapter VIII)
- The vicious circle of heart failure (Chapter X)
- Circulatory insufficiencies (Chapter X)
   - Syncopes
   - Shocks

Respiratory system

The course aims at allowing students to be able to understand human biochemistry and physiology
The different systems will be part of the course:
I. Cardio-vascular system. 
1. Elements of cardio-vascular physiology 2. Cardiac pump 3. Vascular System 4. Cardio-vascular homeostasis : cardiac output and arterial pressure 5. Principles of cardio-vascular physiopathology 6. Arterial hypertension 7. Coronary insufficiency 8. Cardiac failure
II. Respiratory system
1. Introduction to respiratory system 
2. Ventilation
3. Diffusion 
4. Circulation
5. Blood gazes
6. Control of pH
7. Gaz exchanges
8. Respiratory mechanics
9. Control of ventilation
10. Unusual conditions (altitude...). 
 
III. Digestive system 
1. Introduction
2. Regulation processes
3. Energy and metabolism
4. Regulation of intakes
5. Mouth
6. Oesophagus
7. Stomach
8. Hormons of digestive tract
9. Pancreas
10. Intestine absorption 
11. Liver 
12. Colon 
 
IV. Nephro-urinary system 
1. Introduction
2. Glomerular filtration
3. Tubular function
4. Water and ions regulation
5. Kidney pathophysiology 
6. Urinary tract


V. Endocrine system and metabolism
 
The course concerns human biochemistry and physiology, partim endocrine system and metabolism. In particular, it encompasses the following chapters:
1. Introduction
2. Mechanisms of action of hormones
3. The hormones of the energetic metabolism
   Energetic metabolism
   Insulin and diabetes
   Glucagon
   Epinephrine
   Glucocorticoids
   Thyroid hormones
4. Gastro-intestinal hormones
5. Water, electrolytes, and mineral elements
6. Growth
7. Reproduction
8. Cytokines
9. Mediators
 
VI Nervous system
Système sensoriels somatiques : somesthésie, vision, audition, gustation, olfaction
Système moteur somatique : unité motrice, contrôle segmentaire des unités motrices, contrôle supra-segmentaire, apprentissage
Cognition, émotion, comportement
Eveil et conscience
Homéostasie

 

Endocrine system and metabolism

The course deals with normal and pathological human biochemistry and physiology, partim endocrine system and metabolism. In particular, it encompasses the following chapters:
1. Introduction
2. Mechanisms of action of hormones
3. The hormones of energy metabolism      
Energy metabolism      
Insulin and diabetes      
Glucagon      
Adrenaline      
Glucocorticoids      
Thyroid hormones
4. Gastrointestinal hormones
5. Water, electrolytes and mineral elements
6. Growth
7. Reproduction
Chapters VIII (cytokines) and IX (mediators) are removed from this year's materia

Nervous system

6 ntroductory lessons:

  • Overview on nervous system physiology
  • Somatic sensory systems (somesthesia, vision,...)
  • Somatic motor system
  • Vegetative motor system
  • Cognitive systems & state systems
  • Homeostasis
 
The objective of this first part of the module is to introduce students with the fundamentals of physiology/biochemistry of the nervous system and special sense organs.
4 lessons on the pathophysiology and therapeutic stratégies of
  • Nociception (pain)
  • Disorders of the somatic motor systems
  • Disorders of higher functions & emotions
  • Disorders of homeostasis

Digestive system

The course aims at allowing students to be able to understand human biochemistry and physiology

The different systems will be part of the course:

I. Cardio-vascular system. 

1. Elements of cardio-vascular physiology
2. Cardiac pump
3. Vascular System
4. Cardio-vascular homeostasis : cardiac output and arterial pressure
5. Principles of cardio-vascular physiopathology
6. Arterial hypertension
7. Coronary insufficiency
8. Cardiac failure


II. Respiratory system

1. Introduction to respiratory system 

2. Ventilation

3. Diffusion 

4. Circulation

5. Blood gazes

6. Control of pH

7. Gaz exchanges

8. Respiratory mechanics

9. Control of ventilation

10. Unusual conditions (altitude...). 


III. Digestive system 

1. Introduction

2. Regulation processes

3. Energy and metabolism

4. Regulation of intakes

5. Mouth

6. Oesophagus

7. Stomach

8. Hormons of digestive tract

9. Pancreas

10. Intestine absorption 

11. Liver 

12. Colon 

 
IV. Nephro-urinary system 

1. Introduction

2. Glomerular filtration

3. Tubular function

4. Water and ions regulation

5. Kidney pathophysiology 

6. Urinary tract


V. Endocrine system and metabolism

 

The course concerns human biochemistry and physiology, partim endocrine system and metabolism. In particular, it encompasses the following chapters:

1. Introduction

2. Mechanisms of action of hormones

3. The hormones of the energetic metabolism

   Energetic metabolism

   Insulin and diabetes

   Glucagon

   Epinephrine

   Glucocorticoids

   Thyroid hormones

4. Gastro-intestinal hormones

5. Water, electrolytes, and mineral elements

6. Growth

7. Reproduction

8. Cytokines

9. Mediators

 
VI Nervous system

Système sensoriels somatiques : somesthésie, vision, audition, gustation, olfaction

Système moteur somatique : unité motrice, contrôle segmentaire des unités motrices, contrôle supra-segmentaire, apprentissage

Cognition, émotion, comportement

Eveil et conscience

Homéostasie

Nephro-urinary system

The course aims at allowing students to be able to understand human biochemistry and physiology

Nephro-urinary system 

1. Introduction

2. Glomerular filtration

3. Tubular function

4. Water and ions regulation

5. Kidney pathophysiology 

6. Urinary tract

Learning outcomes of the learning unit

The objective of the course is to master the principles of biochemistry and physiology of the human cardio-vascular system. Furthermore, the student will have understood the importance of feedbacks and interactions between the different parts of the regulatory systems.

Cardiovascular system

The objective of the course is to master the principles of biochemistry and physiology of the human cardio-vascular system. Furthermore, the student will have understood the importance of feedbacks and interactions between the different parts of the regulatory systems.
More specifically, the learning objectives correspond to the table of contents of the course, described in detail in the "contents of the teaching unit" section.

Respiratory system

The objective of the course is to master the principles of biochemistry and physiology of the human cardio-vascular system. Furthermore, the student will have understood the importance of feedbacks and interactions between the different parts of the regulatory systems.

Endocrine system and metabolism

The objective of the course is to master the principles of biochemistry and physiology of the human endocrine system and of the metabolism of the human organism. Furthermore, the student will have understood the importance of feedbacks and interactions between the different parts of the regulatory systems.
More specifically, the learning objectives correspond to the table of contents of the course, described in detail in the "contents of the teaching unit" section.

Nervous system

At the end of this course, the student will be able to describe the principles of operation
-general of the nervous system: communication by electrical and chemical signals
-somatic sensory systems (somesthesia, viaion, hearing, olfaction, taste, proprioception)
-the somatic motor system (automatic and voluntary control of muscle strength)
-the vegetative motor system (sympathic and parasympathic)
-the main cognitive functions and state systems (sleep, emotion, consciousness)
-homeostasis control


He will also be able to describe the physiopathological bases of the treatment
- pain
- physical motor disorders
-the main mental disorders
-homeostasis disorders

Digestive system

The objective of the course is to master the principles of biochemistry and physiology of the human systems. Furthermore, the student will have understood the importance of feedbacks and interactions between the different parts of the regulatory systems.

Nephro-urinary system

The objective of the course is to master the principles of biochemistry and physiology of the human systems. Furthermore, the student will have understood the importance of feedbacks and interactions between the different parts of the regulatory systems.

Prerequisite knowledge and skills

General Biochemestry; General Physiology

Cardiovascular system

General Biochemestry; General Physiology

Respiratory system

General Biochemestry; General Physiology

Endocrine system and metabolism

General Biochemestry; General Physiology

Nervous system

General Biochemestry; General Physiology

Digestive system

General Biochemestry; General Physiology

Nephro-urinary system

General Biochemestry; General Physiology

Planned learning activities and teaching methods

Lectures with active participation of students

Cardiovascular system

Lectures with active participation of students. All classes are podcast.

Respiratory system

Lectures with active participation of students

Endocrine system and metabolism

Lectures with active participation of students. All classes are podcast.

Nervous system

N/A

Digestive system

Lectures with active participation of students

Nephro-urinary system

Lectures with active participation of students

Mode of delivery (face to face, distance learning, hybrid learning)

Face-to-face delivery or on-line courses.

Cardiovascular system

Face-to-face delivery

Respiratory system

Face-to-face delivery or on-line lessons.

Endocrine system and metabolism

Face-to-face delivery

Nervous system

Face-to-face delivery
However, these teaching conditions will be adapted according to the requirements of the sanitary situation (COVID-19) and partially or completely moved online into virtual classrooms.

Digestive system

Blended learning


Additional information:

Face-to-face delivery or on-line lessons.

Nephro-urinary system

Blended learning


Additional information:

Face-to-face delivery or on-line lessons

Recommended or required readings

Course syllabus, available on MyULg/eCampus
For neurophysiology here is a useful reference book:
Neurosciences, 5th edition. D. Purves, G.J. Augustine, D. Fitzpatrick, W.C. Hall, A.-S LaMantia, J.O. McNamara, L.E. White. de boeck Ed

Cardiovascular system

Course syllabus, available on MyULg/eCampus

Respiratory system

Course syllabus, available on MyULg/eCampus
For neurophysiology here is a useful reference book:
Neurosciences, 5th edition. D. Purves, G.J. Augustine, D. Fitzpatrick, W.C. Hall, A.-S LaMantia, J.O. McNamara, L.E. White. de boeck Ed

Endocrine system and metabolism

Course syllabus, available on MyULg/eCampus

Nervous system

Course syllabus, available on MyULg/eCampus


Many learning objectives can also be reached by referring the following optional textbooks:

Mayo Clinic Medical Neurosciences: Organized by Neurologic Systems and Levels, (6 edn) 2017              Eduardo E. Benarroch, Jeremy K. Cutsforth-Gregory, Kelly D. Flemming. Edition Oxford academic

Neurosciences, 6ème édition, 2019 (traduite en français). D. Purves, G.J. Augustine, D. Fitzpatrick, W.C. Hall, A.-S LaMantia, J.O. McNamara, L.E. White. Editions de boeck.

 

Digestive system

Course syllabus, available on MyULg/eCampus
For neurophysiology here is a useful reference book:
Neurosciences, 5th edition. D. Purves, G.J. Augustine, D. Fitzpatrick, W.C. Hall, A.-S LaMantia, J.O. McNamara, L.E. White. de boeck Ed<br /><br /> Course syllabus, available on MyULg/eCampus<br /><br /> Course syllabus, available on MyULg/eCampus
For neurophysiology here is a useful reference book:
Neurosciences, 5th edition. D. Purves, G.J. Augustine, D. Fitzpatrick, W.C. Hall, A.-S LaMantia, J.O. McNamara, L.E. White. de boeck Ed<br /><br /> Course syllabus, available on MyULg/eCampus


Many learning objectives can also be reached by referring the following optional textbooks:

Mayo Clinic Medical Neurosciences: Organized by Neurologic Systems and Levels, (6 edn) 2017              Eduardo E. Benarroch, Jeremy K. Cutsforth-Gregory, Kelly D. Flemming. Edition Oxford academic

Neurosciences, 6ème édition, 2019 (traduite en français). D. Purves, G.J. Augustine, D. Fitzpatrick, W.C. Hall, A.-S LaMantia, J.O. McNamara, L.E. White. Editions de boeck.

 <br /><br /> Course syllabus, available on MyULg/eCampus

Nephro-urinary system

Course syllabus, available on eCampus

Assessment methods and criteria

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire )


Additional information:

End semester evaluations



The exams are written. They include the following types of questions:

MCQs with certainty coefficients (see note on this subject on the eCampus).


Examinations will take place as on-line (if needed) or presential activities. 

There is no partial exemption for this course, either between the 1st and 2nd session or from one year to the next for the PHARMA, SBIM and DENTIST sections.

However, this rule does not apply to Master of Science in Nursing students. Partial exemptions may be granted.

Cardiovascular system

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire )


Additional information:

End semester evaluations

Written evaluations will take place in june and in august/september. Evaluations will be organized the same day for all parts of the course Normal and Pathological Human Biochemistry and Physiology (NPHBP). 

For the cardio-vascular module, the exam consists of Multiple Choice Questions (MCQ).

Respiratory system

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire )


Additional information:

End semester evaluations



The exams are written. They include the following types of questions:

MCQs with certainty coefficients (see note on this subject on the eCampus).


Examinations will take place as on-line (if needed) or presential activities. 

There is no partial exemption for this course, either between the 1st and 2nd session or from one year to the next for the PHARMA, SBIM and DENTIST sections.

However, this rule does not apply to Master of Science in Nursing students. Partial exemptions may be granted.

Endocrine system and metabolism

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire )


Additional information:

End semester evaluations



The exams are written. They include the following types of questions:

MCQs with certainty coefficients (see note on this subject on the eCampus).


Examinations will take place as on-line (if needed) or presential activities. 

There is no partial exemption for this course, either between the 1st and 2nd session or from one year to the next for the PHARMA, SBIM and DENTIST sections.

However, this rule does not apply to Master of Science in Nursing students. Partial exemptions may be granted.

.    

Nervous system

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire )


Additional information:

The exams are written. They include the following types of questions:

MCQs with certainty coefficients (see note on this subject on the eCampus).


Examinations will take place as on-line (if needed) or presential activities. 

There is no partial exemption for this course, either between the 1st and 2nd session or from one year to the next for the PHARMA, SBIM and DENTIST sections.

However, this rule does not apply to Master of Science in Nursing students. Partial exemptions may be granted.

Digestive system

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire )


Additional information:

End semester evaluations



The exams are written. They include the following types of questions:

MCQs with certainty coefficients (see note on this subject on the eCampus).


Examinations will take place as on-line (if needed) or presential activities. 

There is no partial exemption for this course, either between the 1st and 2nd session or from one year to the next for the PHARMA, SBIM and DENTIST sections.

However, this rule does not apply to Master of Science in Nursing students. Partial exemptions may be granted.

Nephro-urinary system

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire )


Additional information:

End semester evaluations



The exams are written. They include the following types of questions:

MCQs with certainty coefficients (see note on this subject on the eCampus).


Examinations will take place as on-line (if needed) or presential activities. 

There is no partial exemption for this course, either between the 1st and 2nd session or from one year to the next for the PHARMA, SBIM and DENTIST sections.

However, this rule does not apply to Master of Science in Nursing students. Partial exemptions may be granted.

Work placement(s)

No training

Cardiovascular system

No training

Respiratory system

No training

Endocrine system and metabolism

No training

Nervous system

No training

Nephro-urinary system

No training

Organizational remarks

No remark

Cardiovascular system

No remark

Respiratory system

No remark

Endocrine system and metabolism

No remark

Nervous system

No remark

Nephro-urinary system

No remark

Contacts

Prof Didier CATALDO
didier.cataldo@uliege.be
Tel : 04 366 2521 
Mme Jessica THYS (administrative assistent)
Jessica.thys@uliege.be
 
 Pr Philippe Kolh
Philippe.kolh@uliege.be
04/3665196
04/3668445 (secretary)
 
Prof Gaetan GARRAUX
Tél : 04 3665950
ggarraux@uliege.be

Cardiovascular system

Pr Philippe Kolh
Philippe.kolh@uliege.be
04/3665196
04/3668445 (secretary)
 

Respiratory system

Prof Didier CATALDO
didier.cataldo@uliege.be
Tel : 04 366 2521 
Mme Jessica THYS (administrative assistent)
Jessica.thys@uliege.be
 
 Pr Philippe Kolh
Philippe.kolh@uliege.be
04/3665196
04/3668445 (secretary)
 
Prof Gaetan GARRAUX
Tél : 04 3665950
ggarraux@uliege.be

Endocrine system and metabolism

Pr Philippe Kolh
Philippe.kolh@uliege.be
04/3665196
04/3668445 (secretary)
 

Nervous system

Prof Gaetan GARRAUX ggarraux@uliege.be Tel (Mrs BOURDOUX, secretary): 04/3665950

Digestive system

Prof Didier CATALDO

didier.cataldo@uliege.be

Tel : 04 366 2521 

Mme Jessica THYS (administrative assistent)

Jessica.thys@uliege.be

 

 Pr Philippe Kolh

Philippe.kolh@uliege.be

04/3665196

04/3668445 (secretary)

 

Prof Gaetan GARRAUX

Tél : 04 3665950

ggarraux@uliege.be

Pr Philippe Kolh

Philippe.kolh@uliege.be

04/3665196

04/3668445 (secretary)

 

Nephro-urinary system

Prof Didier CATALDO

didier.cataldo@uliege.be

Tel : 04 366 2521 

Mme Jessica THYS (administrative assistent)

Jessica.thys@uliege.be

 

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